How can we tackle the mechanisms involved in ageing, neurodegenerative diseases and damage to the nervous system?
Research on ageing, neurodegenerative diseases and damage to the nervous system at NeuroMarseille
51 teams study ageing, neurodegenerative diseases (PD, AD, HD, MS, AMD), nervous system lesions (CT, stroke, spinal cord injury, chronic pain) and brain tumours. NeuroMarseille encourages initiatives aimed at discovering the similarities and differences between ageing and disorders in brain function, which will eventually lead to the stratification of patients and a more efficient technology transfer to clinical settings. The excellence of their research, which is based on an interface between fundamental and clinical as well as on the interdisciplinarity of their expertise and approaches, gives national and international visibility to the Marseille teams. In addition, all these teams are also federated within the DHUNE Center of Excellence.
To link it to research, NeuroSchool’s training courses include many course units related to this theme. Below you will find the list of the teams working on this theme as well as the related course units.
The research teams
The multimodal, integrative and translational approaches of the teams aim to: (1) characterise age-related behavioural and molecular abnormalities and develop effective intervention methods to delay the effect of ageing; (2) identify targets for the development of new symptomatic treatments, preventive or curative strategies, based on cell repair or substitution; (3) develop preclinical models with a better capacity for transfer to the clinic and identify markers for early diagnosis, prognosis and treatment effectiveness.
Research teams working on ageing, neurodegenerative diseases and damage to the nervous system
| List of research teams | Team leader(s) | Institutes | Campus |
|---|---|---|---|
| Sensory and Cognitive Rehabilitation | Béatrice. Alescio-Lautier, Liliane Borel | LNSC | Saint-Charles |
| Basal Ganglia, Motivation and Reward | Christelle Baunez | INT | La Timone |
| Brain mapping | Christian-G. Benar | INS | La Timone |
| PhysioNet | Christophe Bernard | INS | La Timone |
| Polarization and binary cell fate decisions in the nervous system | Vincent Bertrand | IBDM | Luminy |
| Development and cognitive aging | Agnès Blaye | LPC | Saint-Charles |
| Plasticity and Physio-pathology of rhythmics Motor networks (P3M) | Frédéric Brocard | INT | La Timone |
| Cognitive Motor Control (CoMCo) | Thomas Brochier | INT | La Timone |
| Attention, cerebral dynamics and chronometry | Boris Burle | LNC | Saint-Charles |
| Molecular bases and pathophysiology of malformations of the cerebral cortex | Carlos Cardoso | INMED | Luminy |
| Perception and attention | Eric Castet, Françoise Vitu | LPC | Saint-Charles |
| Pathophysiology and Therapy of Vestibular Disorder | Christian Chabbert | LNSC | Saint-Charles |
| NEuronal OPerations in visual TOpographic maps | Frédéric Chavane | INT | La Timone |
| Molecular control of neurogenesis | Harold Cremer | IBDM | Luminy |
| Neuronal coding and plasticity in epilepsy | Valérie Crépel | INMED | Luminy |
| Plasticity of neuronal excitability and epilepsy | Dominique Debanne | UNIS | Nord |
| Live imaging of cell interactions in the normal and diseased brain (IMAPATH) | Franck Debardieux | INT | La Timone |
| Plasticity of the Nervous and Muscular Systems | Patrick Decherchi | ISM | La Timone |
| Neural basis of somatosensory functions | Patrick Delmas | LNC | Saint-Charles |
| Social Cognition across Lifespan and Pathologies | Christine Deruelle | INT | La Timone |
| Neuro-inflammation and Multiple Sclerosis | Sophie Desplat-Jégo | INP | La Timone |
| Stem cells and brain repair | Pascale Durbec | IBDM | Luminy |
| Molecular control of mesenchymal cell differentiation | Laurent Fasano | IBDM | Luminy |
| NOSE. Nasal Olfactory Stemness and Epigenesis | François Féron | INP | La Timone |
| Gliomagenesis and MicroEnvironment | Dominique Figarella-branger | INP | La Timone |
| List of research teams | Team leader(s) | Institutes | Campus |
|---|---|---|---|
| Genes, Rhythm and Neurophysiopathology | Anne-Marie François-Bellan | INP | La Timone |
| Micro-RNA & Social Cognition | Eduardo Gascon Gonzalo | INT | La Timone |
| Robustness of excitability | Jean-Marc Goaillard | UNIS | Nord |
| Development and pathologies of neuromuscular circuits | Françoise Helmbacher | IBDM | Luminy |
| Theoretical neurosciences | Viktor Jirsa | INS | La Timone |
| Multisense and body | Anne Kavounoudias | LNSC | Saint-Charles |
| Cellular interactions, neurodegeneration and neuroplasticity | Lydia Kerkerian-Le Goff | IBDM | Luminy |
| Early activity in the developing brain | Roustem Khazipov | INMED | Luminy |
| BBB and neuroinflammation | Michel Khrestchatisky | INP | La Timone |
| Cytoskeleton and Neurophysiopathology | Hervé Kovacic, Vincent Peyrot | INP | La Timone |
| Music, language and writing | Marieke Longcamp | LNC | Saint-Charles |
| Signalling networks for stemness and tumorigenesis | Flavio Maina | IBDM | Luminy |
| Axon plasticity in development and cancer | Fanny Mann | IBDM | Luminy |
| Adolescence and developemental vulnerability to neuropsychiatric diseases | Olivier Manzoni, Pascale Chavis | INMED | Luminy |
| Neural stem cell plasticity | Cédric Maurange | IBDM | Luminy |
| Perinatal Imprintings and Neurodevelopmental Disorders | Françoise Muscatelli-Bossy | INMED | Luminy |
| Stem cells, Disease modeling and Neuroregeneration | Emmanuel Nivet | INP | La Timone |
| Angiogenesis and Tumor Microenvironment | L’houcine Ouafik | INP | La Timone |
| Exploration of the healthy and pathological CNS | Jean-Philippe Ranjeva, Angèle Viola | CRMBM | La Timone |
| Neural Plasticity and Degeneration | Santiago Rivera | INP | La Timone |
| The neural bases of sensorimotor learning | David Robbe, Ingrid Bureau | INMED | Luminy |
| Neurobiology of Mnesic Processes | François Roman | INP | La Timone |
| Dynamics of Cognitive Processes | Daniele Schön | INS | La Timone |
| NICE2: Neonatal, Infantile and Childhood Epilepsies and Encephalopathies | Pierre Szepetowski | INMED | Luminy |
| Brain, Obesity and diet imbalance | Jean-Denis Troadec | LNC | Saint-Charles |
| Human neurogenetics | Laurent Villard | MMG | La Timone |
DHUNE Find out more
Centre of Excellence for Neurodegenerative Diseases and Ageing
The aim of the DHUNE centre of excellence is to boost research and innovation for 5 major diseases: Alzheimer's and Parkinson's, Multiple Sclerosis, Charcot's disease and Huntington's disease.
NeuroSchool Find out more
Education through research
In addition to traditional training related to the theme of research on ageing, neurodegenerative diseases and damage to the nervous system, the teaching team has implemented numerous pedagogical innovations that link research and training.
Courses related to ageing, neurodegenerative diseases and nervous system damage (all levels and specialities combined)
| Course unit | Level |
|---|---|
| States of consciousness and their implications | 3rd year of Bachelor |
| Memory and forgetfulness | 3rd year of Bachelor |
| Environment, lifestyle and nervous system | 3rd year of Bachelor |
| Medication, drugs and the brain | 3rd year of Bachelor |
| Growing old and aging well | 3rd year of Bachelor |
| Functional neuroanatomy | Master |
| Neuroimmunology | Master |
| Neuropharmacology and signalling | Master |
| In vivo brain imaging | Master |
| Learning and memory | Master |
| Emotion, motivation and their dysfunctions | Master |
| Problem-based learning modules: Alzheimer's disease, autism, demyelination, epilepsy, brain-machine interfaces, Parkinson's, mood disorders | Master |
| Clinical days on Parkinson's disease, the brain-machine interface, multiple sclerosis and epilepsy | PhD |
| One-week internships in clinical departments: neurology and ophthalmology; neurology, neuroinflammation, anaesthesia; neurosurgery; neuromuscular disorders and ALS; psychiatry... | PhD |
