Postdoctoral researcher (M/W): Pathogenic mechanisms of Alzheimer's disease.

Description

Postdoctoral researcher responsible for the development and execution of experimental protocols in the context of research projects on the protein actors responsible for synaptic degeneration in Alzheimer’s disease.

Alzheimer’s disease (AD) is one of the greatest scientific and socio-economic challenges of the 21st century. Currently, there is no cure. Aggregates of amyloid-β and tau proteins, along with neuroinflammation/gliosis, are hallmarks of AD that lead to synaptic and neuronal loss as the basis for cognitive decline. The latter is closely related to the brain distribution of tau aggregates, strongly suggesting a link between tau accumulation and synaptic degeneration.

Brain apolipoprotein E (ApoE), primarily produced by astrocytes, is crucial for lipid transport to neurons and synaptic functions. The ApoE4 isoform is the most significant genetic risk factor for AD and contributes to tau-mediated neurodegeneration. Determining how ApoE4 controls tau-mediated synaptic degeneration is essential to understand AD and develop effective treatments, requiring a precise characterization of ApoE4 functions at the synaptic level in tau-damaged synapses.

As a result, the candidate will be involved in a project funded by the ATIP-Avenir program aimed at elucidating the protein partners of ApoE4 underlying tau-mediated synaptic degeneration in AD. To achieve this, the candidate will identify proteomic changes caused by ApoE4 in tau-damaged synapses, combining chemogenetic and proteomic approaches with synaptic resolution. The project involves working with genetically modified mice and analyzing brain phenotypes using proteomic, biochemical, molecular, cellular, and histopathological approaches.

Profil recherché

- Hold a PhD in science, biotechnology, or pharmacological sciences and have research experience in one or more of these fields.
- Be a highly motivated and qualified individual with a strong interest in neuroscience (preferably in neurodegenerative diseases) and technical skills in mass spectrometry (proteomics) and/or biochemistry (click chemistry).
- Ability to analyze proteomic data using recommended software (Proteomic Discoverer, Maxquant/Perseus, etc.).
- Training in animal experimentation and surgery is recommended but not required.
- Knowledge of bioinformatics and programming languages (R, Matlab, Python) is highly appreciated but not mandatory.
- Excellent oral and written communication skills in English.
- Leadership, organizational, and interpersonal skills to work in groups and independently.