Neuronal Network dynamics during cortical development brain
We are interested in the development of neuronal network activities in the somatosensory cortex using a multidisciplinary approach combining in vivo calcium imaging, holographic photostimulation, neuroanatomy, massive data processing, genetics and mouse behavior recordings.
During neocortical development, neurons exhibit highly synchronized patterns of spontaneous activity, with correlated bursts of action potentials dominating network activity. This early activity is replaced before the start of active exploration by sparser, decorrelated activity of cortical neurons. The precise timing and mechanisms of this crucial transition in cortical network activity have not been fully characterized in vivo, the presence and evolution of highly connected cells (hubs) need to be described throughout development and finally the link between network activity and the different waves of neuronal survival need to be further elucidated.
We propose to study these questions by combining in vivo calcium imaging, holographic photostimulation, neuroanatomy, massive data processing, genetics and mouse behavior recordings during the first 2 weeks after birth.
We are looking for a motivated student with either a neurobiology background with a keen interest in computational neuroscience or a physics student with interest in neurobiology and experimentation
The Inmed is one of the most important neuroscience research centers in France. It is a joint Inserm – Aix-Marseille University structure, directed by Rosa Cossart. The main research topics are brain development and plasticity, as well as associated neurological pathologies.