Description de la soumission d'un avis
Offre de stage
Neuro-Immune Alterations caused by Cytomegalovirus (CMV) Infection of the Developing Brain
Période :
au
Overall, the project focuses on one of the most frequent causes of neurodevelopmental disorders, and consists in identifying and in evaluating the role of early cellular (e.g. microglia), molecular (e.g. prostaglandin pathway) and immune (e.g. viral chemokines) alterations in CMV-related neuropathogenesis, using a model of in utero CMV infection of the rat developing brain and a combination of approaches and tools, such as RNA sequencing, flow cytometry, ex vivo patch-clamp and extracellular recordings, in vivo drug assays, nanotools, genetically-engineered rat strains, behavioral tests, etc.