Deciphering the properties and role of long-distance projection GABAergic neurons in epilepsy
Our team is interested in the different neural mechanisms responsible for temporal lobe epilepsy. One of these mechanisms could involve the role played by a particular population of long-distance projection GABAergic neurons. Under "normal" conditions, these neurons coordinate activity within the hippocampus, but also between the hippocampus and other brain regions. Our hypothesis is that the properties of this population are altered in temporal lobe epilepsy, which would disrupt the dynamics of temporal lobe neural networks. To verify this, the student will use a set of in vitro and in vivo experimental strategies, and in particular the patch-clamp recording method on slices of control or epileptic mouse brains. The internship proposal is valid for both the first and second semester of the academic year 2020-2021.
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