Could added complexity in the cortical premotor network of primates become a double-edged sword after stroke?
Numa DANCAUSE, Neuroscience Department, Université de Montréal, Canada
“The refinement of hand movements and the increased complexity of motor behaviors in primates are associated with the establishment of more direct connections of primary motor cortex (M1) neurons onto cervical motoneurons controlling the hand and the appearance of additional premotor motor areas. In contrast to rodents, who appear to have only one premotor area, the frontal cortex of primates has several distinct premotor areas interconnected with M1 and closely involved in movement production. It is not clear how these additional motor areas are interconnected with M1 and how they can participate to the production of motor outputs. After stroke, imaging studies often show atypical hemodynamic activity in premotor areas, in particular in the contralesional hemisphere, but the neurophysiological substrate underlying these changes are also poorly understood. I will first discuss recent data from our laboratory on anatomical and functional connectivity of premotor cortex. Then, I will review some neuroplastic changes we have found in premotor cortex after brain injury, such as stroke. While premotor areas in both hemispheres certainly undergo substantial reorganization, their role in recovery and the factors driving potential vicariation of function are still largely hypothetical.”
June 25th, 2019 – Salle des Voûtes, Saint-Charles campus
- 9:30 am – Discussion among students
- 10:30 am – Seminar (open to everyone)
- 11:30 am – Discussion with speaker for PhD students (register on AMeTICE)