Neuronal coding and plasticity in naïve and epileptic neuronal circuits

Our team is interested in the coding of information in the hippocampus, a structure involved in memory. We focus our works on the dentate gyrus, sitting between the entorhinal cortex and area CA3. This region is both anatomically well positioned and physiologically predisposed to play the role of a gate, blocking or filtering excitatory activity from the entorhinal cortex. We investigate the neuronal computation and plasticity of dentate granule cells in normal and pathological conditions. Our studies are conducted at multiscale levels i.e. from the individual spine to the microcircuit.

Animal model: rodent

Disease conditions: Temporal Lobe Epilepsy

Technical skills: (i) in vitro and in vivo electrophysiological recordings; (ii) calcium imaging; (iii) morphometric analysis; (iv) spatial navigation in virtual reality environments.

Key words: hippocampus, synapse, intrinsic property, plasticity, synaptopathy, calcium

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