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Microglia Alteration and Targeting in Epileptic Encephalopathies

The crucial role of microglia (the brain resident immune cells) in brain development, functioning and disorders is increasingly recognized. Abnormal functioning of the neuronal networks, as seen in various epileptic conditions, is also associated with microglial alteration. However, the exact role played by microglia and by microglia-neuron reciprocal interactions in this pathological developmental context, is still largely undetermined.

We are exploring this question in genetic and nongenetic rodent models of epilepsies and encephalopathies using a multidisciplinary approach that includes pharmacological and molecular genetic tools to deplete or modify microglia, state-of-the-art electrophysiological recordings, two-photon time-lapse imaging, immunohistochemistry and morphology, cellular/molecular biology, flow cytometry and behavioral studies.

Our research is in the core of the research program of INMED/INSERM U1249 and involves complementary collaborations with other research centres in France and abroad.

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