CRMBM - UMR 7339

Center for Magnetic Resonance in Biology and Medicine

Directrice : Monique BERNARD - Chef du service CEMEREM : Maxime GUYE

Faculté de Médecine
27 Boulevard Jean Moulin
13385 Marseille CEDEX 05
France

The The Center for Magnetic Resonance (MR) in Biology and Medicine (CRMBM) conducts translational research by developing and applying MR methods and instruments (RM) to explore the morphology, metabolism and physiology of human diseases and associated animal models (rodents). With the support of methodological and engineering teams, our research teams aim at (i) better characterizing healthy and pathological states of the central nervous, cardiovascular and musculoskeletal systems and (ii) defining new diagnostic and/or therapeutic strategies.

Research is conducted on state-of-the-art MR scanners for rodents at CRMBM (Horizontal 4.7T, vertical 11.75T, and horizontal 7T Bruker systems) and for humans at CEMEREM, the clinical site of CRMBM (Timone University Hospital), equipped with 3 clinical Siemens MR scanners (1.5T, 3T and the first 7T whole-body MR scanner in France).

Pictures from the CRMBM laboratory

Research teams

The CRMBM team, Professor Ranjeva’s team, located at the CEMEREM and working on the human central nervous system, is affiliated to the neuroscience master’s program and can thus train neuroscience master’s students.

INPAC (Imaging Normal and Pathological Central nervous system) (Jean-Philippe Ranjeva (Human CNS) & Angèle Viola (Animal CNS))

The CNS team aims at providing relevant innovative in vivo and non-invasive MRI parameters on patients and rodent models for the better understanding of the pathophysiology, structural abnormalities and dysfunction accompanying or causing some of the main neurological diseases such as multiple sclerosis, epilepsy, and spinal cord injury impacting public health, in close relationships with clinicians from the team and external collaborators specialized also in Alzheimer’s disease, schizophrenia and brain maturation.

MRI explorations are conducted on high field (1.5T, 3T) and ultra high field (7T) clinical MR scanners and on preclinical MR scanners (4.7T, 7T, 11.75T) using advanced MR methods (Diffusion MRI, fMRI, rs-fMRI, MRSI, X-nucleus MRI, QSM, ASL, MTR, …).

Members

Jean-Philippe Ranjeva, Angèle Viola, Virginie Callot, Guillaume Duhamel, Maxime Guye, Jean Pelletier, Bertrand Audoin, Nadine Girard, Sylviane Confort-Gouny, Wafaa Zaaroui, Adriana Perles-Barbacaru, Yann Le Fur, Olivier Girard, Arnaud Le Troter, Adil Maarouf, Audrey Rico, Aude-Marie Grapperon, Annie Verschuren, Patrick Viout, Lauriane Pini, Claire Coste, Isabelle Varlet, Françoise Reuter, Marie-Pierre Ranjeva, Aurélien Massire, Ben Ridley, Henitsoa Rasoandriananina, Samira M’Chinda, Viktor Carvahlo, Andreaa, Simon Levy, Emmanuelle Robinet, Pierre Lehman, Fanelly Pariollaud. Total : 9 HDRs.

Research axes

Characterization of the pathophysiology and clinical consequences of central nervous system pathologies using advanced MRI techniques and neuropsychological and clinical data collected from patients with MS, epilepsy, amyotrophic lateral sclerosis, Alzheimer’s disease, spinal cord injury, schizophrenia and Parkinson’s disease.

Techniques

  • Molecular biology (PCR…)
  •  Biochemistry (Western blot…)
  • Cell culture
  • Immunostaining, histology, flow cytometry
  • Microscopy (fluorescence, confocal, electronic…)
  • Pharmacology
  • Brain imaging and stimulation – Man (fMRI, TMS…)
  • Brain imaging – Animal
  • Electroencephalography (EEG)
  • Medical data analysis

Keywords

Advanced Magnetic Resonance Imaging, fMRI, Spectroscopic MRI, Brain, Spinal Cord, Multiple Sclerosis, Epilepsy, Alzheimer, Amyotrophic Lateral Sclerosis, Stroke, Parkinson, High Field and Ultra High Field clinical and preclinical MR scanners.

Computational neuroscience - Disorders of the nervous system - Excitability, synaptic transmission, network functions - Human cognition and behavior - Novel methods and technology development
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